12-P005 The role of ODZ in retinal connectivity

نویسندگان

  • Andrew Symonds
  • Soyon Chun
  • Rita Pinter
  • Robert Hindges
چکیده

and ectopic expression, we demonstrated that Gata2 regulates GABAergic neuron development in the midbrain, but not in the rhombomere1. Without Gata2, all the precursors in the embryonic midbrain fail to activate GABAergic neuron-specific gene expression and switch to a glutamatergic phenotype instead. Surprisingly, this fate switch is also observed throughout the neonatal midbrain, except for the GABAergic neurons located in the ventral dopaminergic nuclei, suggesting a distinct developmental pathway for these neurons. We have further investigated the origin, developmental history and regulatory mechanisms of these GABAergic neurons associated with the ventral dopaminergic nuclei. The presented studies identify Gata2 as an essential postmitotic selector of the GABAergic neurotransmitter identity and demonstrate developmental heterogeneity of the GABAergic neurons in the midbrain.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Histochemical study of retinal photoreceptors development during pre- and postnatal period and their association with retinal pigment epithelium

Objective(s):The aim of this study was to evaluate distribution and changes of glycoconjugates of retinal photoreceptors during both pre- and postnatal development. Materials and Methods: Tissue sections from days 15 to 20 of Wistar rat embryos and 1 to 12 postnatal days of rat newborns including developing eye were prepared for lectinhistochemistry technique. Horseradish peroxidase (HRP)-label...

متن کامل

Role of Transthoracic Echocardiography in the Evaluation of Patients with Retinal Vein Occlusion

   Introduction: Retinal vein occlusion  is a common vascular disorder disrupting vision. Two basic types of RVO are branch retinal vein occlusion and central retinal vein occlusion (CRVO).  Retinal vein occlusion is a multifactor process including systemic illness and local retinal factors.RVO may be associated with atherosclerotic risk factors. We analyzed the role of 2 dimensional transthor...

متن کامل

Morphological changes in injured retinal pigment epithelium and photoreceptor cells after transplantation of stem cells into subretinal space

Introduction: Degenerative retinal diseases are main cause of irreversible blindness. Stem cells therapy is a promising way in these diseases. Therefore, mesenchymal stem cells because of its safety can produce degenerated cells and can play important role in treatment. The aim of this study was to examine morphological changes in injured retinal pigment epithelium (RPE) and photoreceptor cells...

متن کامل

Eccentric Connectivity Index: Extremal Graphs and Values

Eccentric connectivity index has been found to have a low degeneracy and hence a significant potential of predicting biological activity of certain classes of chemical compounds. We present here explicit formulas for eccentric connectivity index of various families of graphs. We also show that the eccentric connectivity index grows at most polynomially with the number of vertices and determine ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Mechanisms of Development

دوره 126  شماره 

صفحات  -

تاریخ انتشار 2009